Sunday, May 17, 2009

The fibrin - scar tissue connection and what does N-Kinnase have to do with anything?

Article from http://www.ncbi.nlm.nih.gov/pubmed/9670398 on Fibrolynosis and Scar Tissue:

Influence of fibrinolytic factors on scar formation after lumbar discectomy. A magnetic resonance imaging follow-up study with clinical correlation performed 7 years after surgery.

Dullerud R, Graver V, Haakonsen M, Haaland AK, Loeb M, Magnaes B.

Department of Neuroradiology, Ullevaal University Hospital, Oslo, Norway.

STUDY DESIGN: Prospective cohort study. OBJECTIVES: To assess the amount of scar tissue by viewing magnetic resonance images, and to evaluate the correlation between the amount of scar tissue and clinical outcome, surgical technique, and fibrinolytic factors. SUMMARY OF BACKGROUND DATA: The influence of fibrinolytic factors on magnetic resonance images has not been investigated previously. The relation between clinical outcome and findings on magnetic resonance imaging remains uncertain. METHODS: Magnetic resonance imaging at 0.5 Tesla was performed to produce sagittal and axial spin-echo T1-weighted images before and after contrast enhancement on 78 patients 7 years after traditional lumbar discectomy with partial or full laminectomy. Before surgery all patients had been tested for fibrinolytic factors. RESULTS: The overall clinical success rate of the surgery was 73%. No evidence of scar formation was seen in 19 patients, a small amount was seen in 36 patients, a moderate amount in 17 patients, and a large amount was observed in 6 patients. Ten patients who had undergone surgery at two disc levels and 18 who had been treated with full laminectomy exhibited more scar tissue than those patients who had undergone surgery on a single level (P = 0.033) and those who had undergone a partial laminectomy, respectively (P = 0.017). The amount of scar formation also was associated with a poor outcome (P = 0.017) and with low preoperative values of tissue plasminogen activator antigen (P = 0.003) and tissue plasminogen activity (P = 0.048) in samples collected after venous occlusion. The intensity of contrast enhancement, however, was not influenced by these or any other parameters. CONCLUSION: The amount of scar formation after lumbar discectomy seems to be related to the clinical outcome, the size of the surgical exposure, and some fibrinolytic factors.

************For more articles on fibrinolysis see: http://www.ncbi.nlm.nih.gov/pubmed and in the search box enter: "fibrinolysis and scar tissue"

Research thus far indicates N-Kinnase to be of value in regards to fibrinolysis. More research to follow. Watch our web site at www.lifewitharachnoiditis.com for more research we now have in hand to post to share with readers.

4 comments:

  1. Do you worry about having a stroke while you are on your high-dose nattokinase?
    Dru

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  2. Karen Kovacik says: I've been on high dose nattokinnase since November with no ill effects. Your question is, though, do I worry about having a stroke? No .... I'm monitored on a weekly basis and in daily contact, as needed, with my health care provider. Quite honestly, given the choice, I'd probably choose to treat my arachnoiditis even if I had a higher stroke risk. There is a risk of stroke with many pharmaceutials. So, no, I don't worry.

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  4. On conferring with the researcher manufacturing a higher quality nattokinnase, we are advised that nattokinnase is actually used to treat and prevent stroke.

    There has been one incident they are aware of where there was an interaction where the patient was taking aspirin along with the therapy.

    The research will be published soon.

    Note that nattokinnase is only one small portion of the therapy that may help with arachnoiditis and it is wise to focus on the entire group of ingredients used to formulate risk factors.

    This is not intended as medical advice and PLEASE CONSULT YOUR HEALTH CARE PROVIDER.

    LWA

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